Gene chandler - when you're number 1

Gene graduated from Bucyrus High School in 1943 where he was a standout in football and continued to play for the Semi-Pro Football Green Hornets.  He was the fifth generation of his family to be in the plastering business.

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The therapeutic expectations of gene therapy are considerable because of its significant potential for the treatment of inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, such as cancer, acquired immune deficiency syndrome (AIDS), cardiovascular diseases, and certain autoimmune disorders. Gene transfer, or transfection, is a fundamental technique in molecular biology used to manipulate cells or study gene function and protein expression in vitro . When gene transfer is used in disease treatments, it is aimed at curbing genetic diseases by introducing genes coding for functional proteins to cells so as to normalize the cells and even organs. Gene transfer is not only used to treat genetic diseases, but also to produce large quantities of secreted proteins for direct therapeutic application or vaccines production. As is well known, it is difficult for nucleic acids to diffuse directly through plasma membrane due to their size and/or their physicochemical properties, for instance, hydrophilicity. Various strategies for the transfer of nucleic acids, especially genes, have thus been developed [ 8 - 10 ]. The ideal gene delivery and transfection systems should have high transfection efficiency, low toxicity to the cells and single cell specificity, while also is able to simultaneously treat heterogeneous systems with many different cells.

Gene Chandler - When You're Number 1Gene Chandler - When You're Number 1Gene Chandler - When You're Number 1Gene Chandler - When You're Number 1

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